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KMID : 1003219980040010176
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Journal of Korean Oriental Chronic Disease
1998 Volume.4 No. 1 p.176 ~ p.202
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Effect of Gamichungshimtang(GCST) on Circulatory System and Brain Damage
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Abstract
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For the evaluation of effects of GCST A and GCST B, experiments were done on hyperlipidemia induced by administration of cholesterol, thrombosis by dextran, hyperviscosity, hypertension and brain damage.
The results were obtained as follows ;
1. In case of hyperlipidemia induced by cholesterol feed, serum cholesterol, triglyceride, and phospholipid were significantly decreased in both sample groups as compared with data of control.
2. In thrombosis by dextran, fibrinogen was significantly increased and aslo prothrombin time was significantly shortened in both sample groups and FDP was significantly decreased in both sample groups as compared with data of control.
3. In hyperviscosity by hydrocortisone acetate,fibrinogen,prothrombin time, viscosity of whole blood were changed effectively with significance in both sample groups, while numbers of platelet, platelet aggregation were significantly increased and also hematocrit was decreased only in sample group B as compared with data of control.
4. In experiment of hypertension, blood pressure was significantly decreased in both sample groups on the first day after oral administration, while blood pressure was significantly decreased in both sample groups on the 11th day after oral administration to SD rats as compared with data of control.
5. In damage of brain, shortening of coma duration by KCN, extension of survival time to a lethal dose of KCN, extension of breathing time after decapitation and also after ligation of both common carotid arteries and extension of survival time after exposure to anoxia by Co_2, N_2 and vacuum pump were significantly exterted in both sample groups as compared with data of control.
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